Proapoptotic Activity of Bortezomib in Gastrointestinal Stromal Tumor Cells
نویسندگان
چکیده
منابع مشابه
Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells.
Gastrointestinal stromal tumors (GIST) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although >85% of GIST patients treated with the small-molecule inhibitor imatinib mesylate (Gleevec) achieve disease stabilization, complete remissions are rare and a substantial proportion of patients develop resistance to imatinib over time. Upregulation of soluble, n...
متن کاملDesmin expression by a gastrointestinal stromal tumor in a dog
This report describes the histological and immunohistochemical features of a small intestinal tumor that resembled a human gastrointestinal stromal tumor (GISTs) in a seven-year-old male cross-breed dog. This was unique because of the expression of desmin by the tumor. Grossly, the white-gray tumor measured 8.0 × 4.0 × 6.5 cm and was 760 gram in weight. It was cystic and enveloped the jejunum. ...
متن کاملClinical activity of regorafenib in PDGFRA-mutated gastrointestinal stromal tumor
Gastrointestinal stromal tumor (GIST) is the most frequent mesenchymal tumor of the gastrointestinal tract and one of the most frequent sarcoma. Mutually exclusive KIT and PDGFRA mutations are central events in GIST pathogenesis, and their understanding is crucial because specific treatment targeting oncogenic KIT and PDGFRA activation (especially imatinib) has become available. The most freque...
متن کاملacute bleeding in duodenal gastrointestinal stromal tumor
gastrointestinal stromal tumors (gist) are the most common mesenchymal tumors of the gastrointestinal tract. the biological pattern of these tumors ranges from benign-appearing small lesions to malignant sarcomas. only 3%-5% of gists are found in the duodenum. a duodenal gist is a rare source of upper gastrointestinal bleeding. a remarkable percentage of duodenal gists are localized in the thi...
متن کاملGastrointestinal stromal tumor
BACKGROUND GISTs are a subset of mesenchymal tumors and represent the most common mesenchymal neoplasms of GI tract. However, GIST is a recently recognized tumor entity and the literature on these stromal tumors has rapidly expanded. METHODS An extensive review of the literature was carried out in both online medical journals and through Athens University Medical library. An extensive literat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2009
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-09-1449